Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes.

@article{Dedkova2007SignallingMI,
  title={Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes.},
  author={Elena N. Dedkova and Yong Gao Wang and Xiang Ji and Lothar A Blatter and Allen M. Samarel and Stephen L. Lipsius},
  journal={The Journal of physiology},
  year={2007},
  volume={580 Pt 1},
  pages={327-45}
}
In this study we sought to determine whether contractile activity has a role as a signalling mechanism in the activation of intracellular nitric oxide (NO(i)) production induced by electrical stimulation of cat ventricular myocytes. Field stimulation (FS) of single ventricular myocytes elicited frequency-dependent increases in NO(i) that were blocked by the calmodulin (CaM) inhibitor 10 microM W-7 and partially inhibited by the phosphatidylinositol 3'-kinase (PI-(3)K) inhibitor 10 microMm… CONTINUE READING

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