Signalling hypoxia by HIF hydroxylases.

  title={Signalling hypoxia by HIF hydroxylases.},
  author={Christopher J. Schofield and Peter J Ratcliffe},
  journal={Biochemical and biophysical research communications},
  volume={338 1},
Analysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF) transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The enzymes, which catalyse hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-alpha subunits, belong to the superfamily of non-haem Fe(II)-dependent oxygenases that use the citric acid cycle intermediate 2-oxoglutarate (2OG) as a co-substrate. We review biochemical and physiological data that… CONTINUE READING
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