Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.

@article{Fields1997SignallingFA,
  title={Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.},
  author={Timothy A. Fields and Patrick J. Casey},
  journal={The Biochemical journal},
  year={1997},
  volume={321 ( Pt 3)},
  pages={561-71}
}
Pertussis toxin (PTX) has been widely used as a reagent to characterize the involvement of heterotrimeric G-proteins in signalling. This toxin catalyses the ADP-ribosylation of specific G-protein alpha subunits of the Gi family, and this modification prevents the occurrence of the receptor-G-protein interaction. This review focuses on the biochemical properties and signalling of those G-proteins historically classified as 'PTX-resistant' due to the inability of the toxin to influence signalling… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

Target Discovery and Validation Reviews and Protocols

Methods in Molecular Biology™ • 2007
View 9 Excerpts
Highly Influenced

Evidence that G(z)-proteins couple to hypothalamic 5-HT(1A) receptors in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2000
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.

Nature (London) 361

K. J. Swartz, A. Merritt, B. P. Bean, D. M. Lovinger
Proc. Natl. Acad. Sci. U.S.A • 1993

Similar Papers

Loading similar papers…