Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.

  title={Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.},
  author={Timothy A. Fields and Patrick J. Casey},
  journal={The Biochemical journal},
  volume={321 ( Pt 3)},
Pertussis toxin (PTX) has been widely used as a reagent to characterize the involvement of heterotrimeric G-proteins in signalling. This toxin catalyses the ADP-ribosylation of specific G-protein alpha subunits of the Gi family, and this modification prevents the occurrence of the receptor-G-protein interaction. This review focuses on the biochemical properties and signalling of those G-proteins historically classified as 'PTX-resistant' due to the inability of the toxin to influence signalling… CONTINUE READING


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