Signalling complexes and clusters: functional advantages and methodological hurdles.

@article{Cebecauer2010SignallingCA,
  title={Signalling complexes and clusters: functional advantages and methodological hurdles.},
  author={Marek Cebecauer and Martin Spitaler and Arnauld Serg{\'e} and Anthony I. Magee},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 3},
  pages={
          309-20
        }
}
Signalling molecules integrate, codify and transport information in cells. Organisation of these molecules in complexes and clusters improves the efficiency, fidelity and robustness of cellular signalling. Here, we summarise current views on how signalling molecules assemble into macromolecular complexes and clusters and how they use their physical properties to transduce environmental information into a variety of cellular processes. In addition, we discuss recent innovations in live-cell… CONTINUE READING
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