Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

@article{Fortini1992SignallingBT,
  title={Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation},
  author={Mark E. Fortini and Michael A. Simon and Gerald M. Rubin},
  journal={Nature},
  year={1992},
  volume={355},
  pages={559-561}
}
CELL-FATE specification of R7 photoreceptors in the developing Drosophila eye depends on an inductive signal from neighbouring R8 cells. Mutations in three genes, sevenless (sev), bride-of-sevenless (boss) and seven-in-absentia (sina) cause the R7 precursor to become a non-neural cone cell1–3. The sev gene encodes a receptor protein tyrosine kinase (Sev) localized on the R7 surface, activated by a boss-encoded ligand presented by R8 (refs 4–6). The sina gene encodes a nuclear factor required in… CONTINUE READING
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