Signalling by the p60c-src family of protein-tyrosine kinases.

  title={Signalling by the p60c-src family of protein-tyrosine kinases.},
  author={Panos Kefalas and Timothy R P Brown and Paul M. Brickell},
  journal={The international journal of biochemistry & cell biology},
  volume={27 6},
The c-src gene family has nine known members (blk, c-fgr, fyn, hck, lck, lyn, c-src, c-yes and yrk), each encoding a cytoplasmic protein-tyrosine kinase (PTK) believed to be involved in signal transduction. The c-src PTKs contain three domains (SH1, SH2 and SH3) that are found in many other signalling proteins. The SH1 domain has PTK activity, whilst the SH2 and SH3 domains are involved in mediating protein-protein interactions by binding to phosphotyrosine-containing and proline-rich motifs… CONTINUE READING


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