Signalling by the global regulatory molecule ppGpp in bacteria and chloroplasts of land plants.

@article{Tozawa2011SignallingBT,
  title={Signalling by the global regulatory molecule ppGpp in bacteria and chloroplasts of land plants.},
  author={Yuzuru Tozawa and Yoshitaka Nomura},
  journal={Plant biology},
  year={2011},
  volume={13 5},
  pages={
          699-709
        }
}
The hyperphosphorylated guanine ribonucleotide ppGpp mediates the stringent response in bacteria. Biochemical and genetic studies of this response in Escherichia coli have shown that the biosynthesis of ppGpp is catalysed by two homologous enzymes, RelA and SpoT. RelA is activated in response to amino acid starvation, and SpoT responds to abiotic physical stress beside nutritional stress. All free-living bacteria, including Gram-positive firmicutes, contain RelA-SpoT homologues (RSH). Further… CONTINUE READING

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