Signalling by protein phosphatases and drug development: a systems-centred view.

  title={Signalling by protein phosphatases and drug development: a systems-centred view.},
  author={Lan K. Nguyen and David Matallanas and David R. Croucher and Alexander F von Kriegsheim and Boris N. Kholodenko},
  journal={The FEBS journal},
  volume={280 2},
Protein modification cycles catalysed by opposing enzymes, such as kinases and phosphatases, form the backbone of signalling networks. Although, historically, kinases have been at the research forefront, a systems-centred approach reveals predominant roles for phosphatases in controlling the network response times and spatio-temporal profiles of signalling activities. Emerging evidence suggests that phosphatase kinetics are critical for network function and cell-fate decisions. Protein… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…