Signalling by protein phosphatases and drug development: a systems-centred view.

@article{Nguyen2013SignallingBP,
  title={Signalling by protein phosphatases and drug development: a systems-centred view.},
  author={Lan K. Nguyen and David Matallanas and David R. Croucher and Alexander F von Kriegsheim and Boris N. Kholodenko},
  journal={The FEBS journal},
  year={2013},
  volume={280 2},
  pages={751-65}
}
Protein modification cycles catalysed by opposing enzymes, such as kinases and phosphatases, form the backbone of signalling networks. Although, historically, kinases have been at the research forefront, a systems-centred approach reveals predominant roles for phosphatases in controlling the network response times and spatio-temporal profiles of signalling activities. Emerging evidence suggests that phosphatase kinetics are critical for network function and cell-fate decisions. Protein… CONTINUE READING
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