Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration

@article{Gilbert2016SignallingBT,
  title={Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration},
  author={R. Gilbert and M. Vickaryous and A. Viloria-Petit},
  journal={Journal of Developmental Biology},
  year={2016},
  volume={4}
}
Transforming growth factor beta (TGFβ) signalling is essential for wound healing, including both non-specific scar formation and tissue-specific regeneration. Specific TGFβ isoforms and downstream mediators of canonical and non-canonical signalling play different roles in each of these processes. Here we review the role of TGFβ signalling during tissue repair, with a particular focus on the prototypic isoforms TGFβ1, TGFβ2, and TGFβ3. We begin by introducing TGFβ signalling and then discuss the… Expand
Diverse Signaling by TGFβ Isoforms in Response to Focal Injury is Associated with Either Retinal Regeneration or Reactive Gliosis
TLDR
The regenerative versus reparative effect of the TGFβ pathway observed may rely on the activation of different signaling cascades, which provides one explanation of the different injury response in zebrafish and mouse retina. Expand
Role of Transforming Growth Factor Beta Family in Angiogenesis
TLDR
An overview of knowledge accumulated to date on TGFβ’s role in angiogenesis as well as vascular biology and vascular disease is presented, and potential applications of this knowledge to the treatment of angiogenic-dependent diseases such as cancer are discussed. Expand
The Role of TGF Beta 1 and PDGF BB in Wound Healing of the Palate
TLDR
TGF-β and PDGF, being one of the major growth factors in oral wound healing is found to play a pivotal role in tissue healing of the palatal mucosa after an injury. Expand
Smad7 Ameliorates TGF-β-Mediated Skin Inflammation and Associated Wound Healing Defects but Not Susceptibility to Experimental Skin Carcinogenesis.
TLDR
The study suggests the feasibility of using exogenous Smad7 below an oncogenic level to alleviate skin inflammation and wound healing defects associated with excessive activation of TGF-β and NF-κB. Expand
TGF-β1 Pretreatment Improves the Function of Mesenchymal Stem Cells in the Wound Bed
TLDR
It is demonstrated that pretreatment of MSCs with the mechano-stimulatory soluble factor transforming growth factor (TGF-β1), which is highly expressed in injury sites, improves wound closure in a syngeneic murine wound model, and suggests that defined chemical stimuli can benefit site specific adaptability of M SCs to improve their function and therapeutic usefulness. Expand
VEGF, FGF‐2 and TGFβ expression in the normal and regenerating epidermis of geckos: implications for epidermal homeostasis and wound healing in reptiles
TLDR
It is proposed that the ubiquitous pattern of growth factor expression by keratinocytes is associated with various roles during tissue homeostasis, including protection against ultraviolet photodamage and coordinated body‐wide skin shedding. Expand
Human Skin Keratinocytes on Sustained TGF-β Stimulation Reveal Partial EMT Features and Weaken Growth Arrest Responses
TLDR
An in vitro model validated for the study of epidermal physiology and function is used, the HaCaT cells, to provide a description of the impact of sustained exposure to TGF-β, and the proposed setting might offer a useful framework for future research on the mechanisms driving wound chronification. Expand
Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound
TLDR
The overall effect of COX-2 inhibitor was shortening of the inflammatory phase of wound healing with subsequent minimization of the associated tissue destruction and consequently improvement of the scar quality. Expand
Mechanisms of TGFβ3 Action as a Therapeutic Agent for Promoting the Synthesis of Extracellular Matrix Proteins in Hyaline Cartilage
TLDR
The effects of TGFβ3 on the receptor complex activation and subsequent intracellular trafficking of Smad proteins are described and the relation between these processes and upregulation of expression of major extracellular matrix genes, such as col2a1 and acan are analyzed. Expand
Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective
TLDR
Previously, low TGF-β levels have been suggested as a pattern in chronic wounds, but a revision of the available evidence in humans indicates that this could constitute a questionable argument, and existing evidence on the roles played by T GF-β during skin wound healing is compiled, with special emphasis on keratinocyte responses. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 203 REFERENCES
The Role of TGFβ Signaling in Wound Epithelialization.
TLDR
A better understanding of TGFβ signaling may provide new insights not only in the normal epithelialization process, but also in tissue regeneration, which may lead to development of novel therapeutic advances for chronic wounds. Expand
Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing
TLDR
How the TGF-β family and Endoglin, regulate stem cell availability, and modulate cellular behavior within the wound microenvironment is explored, including current knowledge of the signaling pathways involved, and how this information may be applicable to inflammatory and/or angiogenic diseases such as fibrosis, rheumatoid arthritis and metastatic cancer is explored. Expand
TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
TLDR
Several spatially and temporally distinct roles for TGF-beta signaling during regeneration are revealed: (1) wound epithelium formation, (2) establishment of regeneration bud structures and signaling cascades, and (3) regulation of cell proliferation. Expand
Transforming Growth Factor Beta 3 Is Required for Excisional Wound Repair In Vivo
TLDR
It is demonstrated that TGF-ß 3 does not promote epithelialization and is necessary for wound closure as wounds injected with neutralizing antibody against TGF -ß 3 showed increased epidermal volume and proliferation in conjunction with a delay in keratinocyte migration. Expand
TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling.
TLDR
It is shown for the first time that synthesis of CTGF in cultures of human corneal epithelial cells is induced by TGFbeta through the Ras/MEK/ERK MAPK signalling pathway and that this is required for re-epithelialisation to occur through cell migration, revealing a novel function forCTGF in the regulation of epithelial tissue repair beyond its established role in fibrosis. Expand
Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosis
TLDR
TGF‐β3 may offer a scar‐reducing therapy for acute and chronic wounds and fibrosing disorders. Expand
Role of Transforming Growth Factor Beta in Angiogenesis
TLDR
An overview of knowledge accumulated to date on TGFβ’s role in angiogenesis as well as vascular biology and vascular disease is presented and potential applications of this knowledge to the treatment of angiogenic-dependent diseases such as cancer are discussed. Expand
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
TLDR
It is reported that Smad3-null (Smad3ex8/ex8) mice paradoxically show accelerated cutaneous wound healing compared with wild-type mice, characterized by an increased rate of re-epithelialization and significantly reduced local infiltration of monocytes. Expand
Exploring anti-TGF-β therapies in cancer and fibrosis
Transforming growth factor-β (TGF-β) is a multifunctional cytokine, with important roles in maintaining tissue homeostasis. TGF-β signals via transmembrane serine/threonine kinase receptors andExpand
Regulation of wound healing by growth factors and cytokines.
TLDR
This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds and reports on genetic studies addressing the functions of endogenous growth factors in the wound repair process. Expand
...
1
2
3
4
5
...