Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.

@article{Kemp2006SignallingBH,
  title={Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.},
  author={Lawrence Kemp and Barbara Mulloy and Ermanno Gherardi},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 3},
  pages={
          414-7
        }
}
The receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration. Aberrant signalling of this complex is also a feature of many tumours and appears to contribute to the growth, invasiveness and metastasis of both carcinomas and sarcomas. HGF/SF, like many other angiogenic growth factors, employs heparan sulphate as co-receptor. The role of this interaction has not been… Expand
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TLDR
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