Signalling ballet in space and time

@article{Kholodenko2010SignallingBI,
  title={Signalling ballet in space and time},
  author={Boris N. Kholodenko and John F Hancock and Walter Kolch},
  journal={Nature Reviews Molecular Cell Biology},
  year={2010},
  volume={11},
  pages={414-426}
}
Although we have amassed extensive catalogues of signalling network components, our understanding of the spatiotemporal control of emergent network structures has lagged behind. Dynamic behaviour is starting to be explored throughout the genome, but analysis of spatial behaviours is still confined to individual proteins. The challenge is to reveal how cells integrate temporal and spatial information to determine specific biological functions. Key findings are the discovery of molecular… CONTINUE READING

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