Signalling In The Epidermis: The E2f Cell Cycle Regulatory Pathway In Epidermal Morphogenesis, Regeneration And Transformation

@article{Ivanova2005SignallingIT,
  title={Signalling In The Epidermis: The E2f Cell Cycle Regulatory Pathway In Epidermal Morphogenesis, Regeneration And Transformation},
  author={Iordanka A. Ivanova and Sudhir J. A. D'souza and Lina Dagnino},
  journal={International Journal of Biological Sciences},
  year={2005},
  volume={1},
  pages={87 - 95}
}
The epidermis is the outermost layer in the skin, and it is the first line of defence against the environment. The epidermis also provides a barrier against loss of fluids and electrolytes, which is crucial for life. Essential in the maintenance of this tissue is its ability to continually self-renew and regenerate after injury. These two characteristics are critically dependent on the ability of the principal epidermal cell type, the keratinocyte, to proliferate and to respond to… CONTINUE READING
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