Signalling: Fine-tuning of inflammation by F-box proteins

  title={Signalling: Fine-tuning of inflammation by F-box proteins},
  author={Yvonne Bordon},
  journal={Nature Reviews Immunology},
  • Yvonne Bordon
  • Published 25 April 2013
  • Biology
  • Nature Reviews Immunology
(TRAFs) are crucial adaptor proteins that link membrane-bound immune receptors (including tumour necrosis factor (TNF) receptors and Toll-like receptors) to downstream signalling cascades. Chen et al. now report that F-box and leucine-rich repeat protein 2 (FBXL2) and F-box only protein 3 (FBXO3) fine-tune pro-inflammatory cytokine production by regulating the stability of TRAFs. F-box proteins contribute to ubiquitin-mediated responses by providing substrate specificity to the SKP1–CUL1–F-box… 


A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation
A pathway of innate immunity that may be useful to detect subjects with altered immune responses during critical illness or provide a basis for therapeutic intervention targeting TRAF protein abundance is identified.