Signalisation apeline et physiopathologie vasculaire

@article{Masri2009SignalisationAE,
  title={Signalisation apeline et physiopathologie vasculaire},
  author={B. Masri and L. V. Berghe and Caroline Sorli and B. Knibiehler and Yves Audigier},
  journal={Biologie Aujourd'hui},
  year={2009},
  volume={203},
  pages={171-179}
}
Le developpement du systeme vasculaire est une etape precoce de l'organogenese qui met en jeu de nombreuses voies de signalisation. L'integration des signaux decodes par divers recepteurs membranaires orchestre les evenements cellulaires qui interviennent a differents stades, de la formation du reseau vasculaire primitif par vasculogenese jusqu'au remodelage en arbre vasculaire complexe par angiogenese. Notre laboratoire a montre le role d'une nouvelle voie de signalisation dans l'angiogenese… Expand
20 Citations
APELIN IN EPIRETINAL FIBROVASCULAR MEMBRANES OF PATIENTS WITH RETINOPATHY OF PREMATURITY AND THE CHANGES AFTER INTRAVITREAL BEVACIZUMAB
TLDR
The present results showed that the effect of apelin was related to HIF-1a but independent with VEGF, and the apelin/APJ system may be involved in the development of retinal neovascularization of ROP. Expand
Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction.
TLDR
The expression of apelin and its receptor APJ were exclusively expressed on newly formed lymphatic vasculature in a pathological model of myocardial infarction and demonstrated that apelin plays a key role in lymphatic vessel maturation and stability in pathological settings. Expand
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism
TLDR
Novel data provide evidence for a physiological role of APJ/NTSR1 heterodimers in terms of ERK1/2 activation and increased intracellular calcium and induced cell proliferation and provide potential new pharmaceutical targets for cardiovascular disease. Expand
Apelin/APJ signaling in hypoxia-related diseases.
TLDR
The properties of the apelin/APJ system, which is affected by hypoxic conditions, and the regulation of apelin-APJ signaling in hypoxia-associated disorders are reviewed to review. Expand
Elucidation of the Structure–Activity Relationships of Apelin: Influence of Unnatural Amino Acids on Binding, Signaling, and Plasma Stability
TLDR
Synthesis of analogues of apelin‐13 modified at selected positions with unnatural amino acids, with a particular emphasis on the C‐terminal portion found to possess increased binding and higher stability than the parent peptide. Expand
Mechanism of Wnt/β-catenin signaling pathway in enhanced malignant phenotype of non-small cell lung cancer induced by anti-angiogenesis therapy.
TLDR
For the anti-angiogenesis therapy, the inhibited expression of VEGF can activate the Wnt/β-catenin signaling pathway to cause the epithelial mesenchymal transition and then the enhanced malignant phenotype of non-small cell lung cancer. Expand
Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer
TLDR
The in vitro study revealed that the Apelin regulated the migration and invasion abilities of GC cell lines, accompanied by up-regulations of a variety of cytokines associated with tumor invasiveness. Expand
Apelin/APJ system: A potential therapeutic target for endothelial dysfunction‐related diseases
TLDR
The role of apelin/APJ on endothelial dysfunction‐related diseases including atherosclerosis, diabetes, hypertension, and myocardial infarction is analyzed and the most commonly used agonists and antagonists of APJ are summarized. Expand
Apelin in epiretinal membranes of patients with proliferative diabetic retinopathy
TLDR
Investigation of the correlation between apelin and ERMs after PDR showed that apelin was involved in the formation of ERMs and promoted theformation of adventitia, including glial, endothelial, and RPE cells. Expand
Apelin Receptor Signaling Protects GT1-7 GnRH Neurons Against Oxidative Stress In Vitro.
TLDR
The present findings suggest that expression and activation of APLNR in Gn RH releasing GT1-7 neurons might induce a protective mechanism against oxidative stress induced cell death and APL NR signaling may play a role in GnRH neurons. Expand
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References

SHOWING 1-10 OF 26 REFERENCES
Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis.
TLDR
The results define apelin and APJ as genes of potential diagnostic value and promising targets for the development of a new generation of anti-tumor angiogenic drugs. Expand
Expression of a new G protein-coupled receptor X-msr is associated with an endothelial lineage in Xenopus laevis
TLDR
The name of X-msr is proposed for mesenchyme-associated serpentine receptor, a novel member of the G protein-coupled receptor superfamily in Xenopus that traces an endothelial lineage and represents a very early and unique marker in xenopus of the specification of cardiac and vascular endothelia. Expand
Apelin is a potent activator of tumour neoangiogenesis
TLDR
In tumours derived from TS/A-apelin clones, the expression of the endothelial marker CD31 was increased and revealed the formation of large intratumoral vessels lined with CD31 positive cells, suggesting that apelin behaves as a potent activator of tumour neoangiogenesis by a paracrine effect on host vessels. Expand
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
TLDR
It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells. Expand
Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis
TLDR
Results indicated that the apelin/APJ system is involved in the regulation of blood vessel diameter during angiogenesis, and apelin enhanced endothelial cell proliferation in the presence of vascular endothelial growth factor and promoted cell‐to‐cell aggregation. Expand
Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo.
TLDR
Embryonic expression studies and gain of function experiments indicate that apelin is required for normal vascular development in the frog embryo and has properties consistent with a role during normal and pathological angiogenesis. Expand
Xapelin and Xmsr are required for cardiovascular development in Xenopus laevis.
TLDR
It is demonstrated that Xenopus apelin and Xmsr play pivotal roles in cardiovascular development and forced expression of constitutive active G alpha i rescued the phenotypes ofXmsr morpholino-injected embryos, indicating that the i/o type of G protein alpha subunit acts downstream of XmsR. Expand
Apelin is a novel angiogenic factor in retinal endothelial cells.
There has been much focus recently on the possible functions of apelin, an endogenous ligand for the orphan G-protein-coupled receptor APJ, in cardiovascular and central nervous systems. We report aExpand
The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors.
TLDR
It is shown that zebrafish grinch (grn) mutants form a reduced number of myocardial progenitor cells, which results in a profound deficit in cardiomyocyte numbers in the most severe cases, and support a model in which agtrl1b regulates the migration of cells fated to form myocardium progenitors. Expand
Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.
TLDR
The results suggest that dominantly acting ras oncogenes may contribute to the growth of solid tumors in vivo not only by a direct effect on tumor cell proliferation but also indirectly, i.e., by facilitating tumor angiogenesis. Expand
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