Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.

@article{Feng2006SignalingWA,
  title={Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.},
  author={Qin Fu Feng and Ping Yi and Jiemin Wong and Bert W O'malley},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 21},
  pages={7846-57}
}
Recent studies indicate that steroid receptor-mediated transcriptional initiation is a cyclical process involving multiple rounds of coactivator assembly and disassembly. Steroid receptor coactivator 3 (SRC-3) coactivator phosphorylation has been shown to regulate coactivator complex assembly, but the mechanisms by which coactivator disassembly is triggered are not well understood. In this study, we provide in vitro and in vivo evidence that members of the SRC coactivator family serve as… CONTINUE READING
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