Signaling via LTβR on the lamina propria stromal cells of the gut is required for IgA production

@article{Kang2002SignalingVL,
  title={Signaling via LTβR on the lamina propria stromal cells of the gut is required for IgA production},
  author={Hoin Kang and Robert K. Chin and Yang Wang and Ping Yu and Jun Wang and Kenneth A. Newell and Yang-Xin Fu},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={576-582}
}
Peyer's patches (PPs) and/or mesenteric lymph nodes (MLNs) are thought to be essential for immunoglobulin A (IgA) production. We found that the severe IgA deficiency in lymphotoxin-deficient (LT−/−) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs. The number of IgA precursors from LT−/− mice was not reduced, and they were able to migrate into the lamina propria (LP) of wild-type mice but not of LTβR−/− mice. Consistently… CONTINUE READING

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Peyer's patches are required for oral tolerance to proteins.

Proceedings of the National Academy of Sciences of the United States of America • 2001

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