Signaling transduction pathway of angiotensin II in human mesangial cells: mediation of focal adhesion and GTPase activating proteins.

@article{Shikata1999SignalingTP,
  title={Signaling transduction pathway of angiotensin II in human mesangial cells: mediation of focal adhesion and GTPase activating proteins.},
  author={Yasushi Shikata and Kenichi Shikata and Mitsuhiro Matsuda and Hidehiro Sugimoto and Jun Wada and Hirofumi Makino},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={257 1},
  pages={234-8}
}
Human mesangial cells (HMCs) respond to angiotensin II stimulation, which modulates their physiological activities, i.e., contraction and proliferation. It has been revealed that focal adhesion kinase (FAK) and paxillin participate in the angiotensin II-mediated signaling and cytoskeletal rearrangements at focal adhesion. We investigated the influences of cell adhesion upon angiotensin II effects in HMCs. In adherent cells, both FAK and paxillin were tyrosine phosphorylated by angiotensin II… CONTINUE READING