Signaling to p53: breaking the posttranslational modification code.

  title={Signaling to p53: breaking the posttranslational modification code.},
  author={Ettore Appella and Carl W. Anderson},
  volume={48 3},
In unstressed cells, the tumor suppressor protein p53, a tetrameric transcription factor, is present in a latent state and is maintained at low levels through targeted degradation. A variety of cellular stresses including DNA damage, hypoxia, nucleotide depletion, viral infection, and cytokine-activated signaling pathways that transiently stabilize the p53 protein, cause it to accumulate in the nucleus, and activate it as a transcription factor. Activation leads either to growth arrest at the… CONTINUE READING
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