Signaling to NFk B : Regulation by Ubiquitination

  title={Signaling to NFk B : Regulation by Ubiquitination},
  author={Ingrid E. Wertz and Vishva M. Dixit},
The NF-kB pathway is a ubiquitous stress response that activates the NF-kB family of transcription factors. Antigen receptors, receptors of the innate immune system, and certain intracellular stressors are potent activators of this pathway. The transcriptional program that is activated is both antiapoptotic and highly proinflammatory. Indeed, any compromise in engagement of the pathway results in immunodeficiency, whereas constitutive activation generates a sustained inflammatory response that… CONTINUE READING


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