Signaling through the TGF Beta-Activin Receptors ALK4/5/7 Regulates Testis Formation and Male Germ Cell Development

@inproceedings{Miles2013SignalingTT,
  title={Signaling through the TGF Beta-Activin Receptors ALK4/5/7 Regulates Testis Formation and Male Germ Cell Development},
  author={Denise C. Miles and Stephanie I. Wakeling and Jessica M. Stringer and Jocelyn van den Bergen and Dagmar Wilhelm and Andrew H. Sinclair and Patrick S Western},
  booktitle={PloS one},
  year={2013}
}
The developing testis provides an environment that nurtures germ cell development, ultimately ensuring spermatogenesis and fertility. Impacts on this environment are considered to underlie aberrant germ cell development and formation of germ cell tumour precursors. The signaling events involved in testis formation and male fetal germ cell development remain largely unknown. Analysis of knockout mice lacking single Tgfβ family members has indicated that Tgfβ's are not required for sex… CONTINUE READING
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