Signaling through ephrin-A ligand leads to activation of Src-family kinases, Akt phosphorylation, and inhibition of antigen receptor-induced apoptosis.

@article{Holen2008SignalingTE,
  title={Signaling through ephrin-A ligand leads to activation of Src-family kinases, Akt phosphorylation, and inhibition of antigen receptor-induced apoptosis.},
  author={Halvor Lauvstad Holen and Mohsen Shadidi and Kristina Narvhus and Oddveig Kj\osnes and Anne M Tierens and H B M Aasheim},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={84 4},
  pages={1183-91}
}
Eph receptor tyrosine kinases and ephrins play important roles in diverse biological processes such as migration, adhesion, and angiogenesis. Forward and reverse signaling has been reported in receptor- and ligand-bearing cells. The ligands can be divided into the transmembrane ephrin-B family and the GPI-anchored ephrin-A family. Here, we show expression of ephrin-A ligands on CD4+ T cells cultured in medium with human serum and the T cell line Jurkat TAg and on cells isolated from patients… CONTINUE READING
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