Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance.

@article{You2010SignalingTT,
  title={Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance.},
  author={Jia You and Yue Yu and Lei Jiang and Wenxia Li and Xinxin Yu and Lety Gonzalez and Guoqing Yang and Zunji Ke and Wenjun Li and Cai Fu Li and Yong Liu},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 7},
  pages={
          1650-9
        }
}
Leptin regulates energy homeostasis through central activation of multiple signaling pathways mediated by Ob-Rb, the long form of leptin receptor. Leptin resistance underlies the pathogenic development of obesity, which is closely associated with environmental factors. To further understand the physiological function of leptin signaling mechanisms, we generated a knock-in line of mice (Y985F) expressing a mutant Ob-Rb with a phenylalanine substitution for Tyr985, one of the three intracellular… CONTINUE READING
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