Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.

@article{Northey2008SignalingTS,
  title={Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.},
  author={Jason Jonathan Northey and Juliann Chmielecki and Elaine Ngan and Caterina Russo and Matthew G. Annis and William J. Muller and Peter M Siegel},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 10},
  pages={3162-76}
}
Cooperation between the Neu/ErbB-2 and transforming growth factor beta (TGF-beta) signaling pathways enhances the invasive and metastatic capabilities of breast cancer cells; however, the underlying mechanisms mediating this synergy have yet to be fully explained. We demonstrate that TGF-beta induces the migration and invasion of mammary tumor explants expressing an activated Neu/ErbB-2 receptor, which requires signaling from autophosphorylation sites located in the C terminus. A systematic… CONTINUE READING