Signaling through RAS-RAF-MEK-ERK: from basics to bedside.

  title={Signaling through RAS-RAF-MEK-ERK: from basics to bedside.},
  author={Armin Zebisch and A. P. Czernilofsky and Gy{\"o}rgy K{\'e}ri and Julja Smigelskaite and Heinz Sill and J Troppmair},
  journal={Current medicinal chemistry},
  volume={14 5},
Aberrant signaling caused by mutations in the RAS-RAF-MEK-ERK pathway and its upstream activators critically contributes to human tumor development. Strategies, which aim at inhibiting hyperactive signaling molecules, appear conceptually straight forward, but their translation into clinical practice has been hampered by many setbacks. Understanding structure, function and regulation of this intracellular pathway as well as its crosstalk with other signaling activities in the cell will be… CONTINUE READING


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