Signaling through NO and cGMP-dependent protein kinases.

@article{Schlossmann2003SignalingTN,
  title={Signaling through NO and cGMP-dependent protein kinases.},
  author={Jens Schlossmann and Robert Feil and Franz Hofmann},
  journal={Annals of medicine},
  year={2003},
  volume={35 1},
  pages={
          21-7
        }
}
The gaseous molecule nitric oxide (NO) modulates a large variety of physiological functions including vascular tone, intestinal motility, platelet aggregation, proliferation, apoptosis, and neurotransmission. NO initiates diverse cellular signaling cascades which comprise nitrosylation of proteins, adenosine 5'-diphosphate (ADP)-ribosylation, or stimulation of soluble guanylyl cyclases which catalyze intracellular guanosine 3',5'-cyclic monophosphate (cGMP) synthesis. cGMP activates cGMP… CONTINUE READING

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