Signaling through IL-17C/IL-17RE Is Dispensable for Immunity to Systemic, Oral and Cutaneous Candidiasis

@inproceedings{Conti2015SignalingTI,
  title={Signaling through IL-17C/IL-17RE Is Dispensable for Immunity to Systemic, Oral and Cutaneous Candidiasis},
  author={Heather R Conti and Natasha Whibley and Bianca M Coleman and Abhishek V. Garg and Jillian R. Jaycox and Sarah L Gaffen},
  booktitle={PloS one},
  year={2015}
}
Candida albicans is a commensal fungal microbe of the human orogastrointestinal tract and skin. C. albicans causes multiple forms of disease in immunocompromised patients, including oral, vaginal, dermal and disseminated candidiasis. The cytokine IL-17 (IL-17A) and its receptor subunits, IL-17RA and IL-17RC, are required for protection to most forms of candidiasis. The importance of the IL-17R pathway has been observed not only in knockout mouse models, but also in humans with rare genetic… CONTINUE READING
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