Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.

@article{Garca2005SignalingTF,
  title={Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.},
  author={C. Mart{\'i}nez Garc{\'i}a and Kai Yu and Haotian Zhao and Ruth Ashery-Padan and David M Ornitz and M. L. Robinson and David C. Beebe},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2005},
  volume={233 2},
  pages={516-27}
}
Fibroblast growth factors (FGFs) play important roles in many aspects of development, including lens development. The lens is derived from the surface ectoderm and consists of an anterior layer of epithelial cells and elongated, terminally differentiated fiber cells that form the bulk of the tissue. FGF signaling has been implicated in lens induction, proliferation, and differentiation. To address the role of FGFs in lens development, we inactivated FGF receptor-2 (Fgfr2) using a Cre transgene… CONTINUE READING
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