Signaling through CD38 induces NK cell activation.

  title={Signaling through CD38 induces NK cell activation.},
  author={Roberto Mallone and Ada Funaro and Mercedes Zubiaur and Germano Baj and Clara Maria Ausiello and Carlo Tacchetti and Jaime Ferrer Sancho and C Grossi and Fabio Malavasi},
  journal={International immunology},
  volume={13 4},
Human CD38 is a signal transduction molecule, and, concurrently, an ectoenzyme catalyzing the synthesis and degradation of cyclic ADP-ribose (cADPR), a potent Ca2+ mobilizer. One facet of CD38 that has not yet been addressed is its role in NK cells. To this end, the events triggered by CD38 ligation with agonistic mAb were analyzed on freshly purified human NK cells. Ligation was followed by (i) a significant rise in the intracellular level of Ca2+, (ii) increased expression of HLA class II and… CONTINUE READING
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