Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

@inproceedings{Kwan2013SignalingTC,
  title={Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells},
  author={Wing-Hong Kwan and William van der Touw and Estela Paz-Artal and Ming O Li and Peter S Heeger},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Thymus-derived (natural) CD4(+) FoxP3(+) regulatory T cells (nT reg cells) are required for immune homeostasis and self-tolerance, but must be stringently controlled to permit expansion of protective immunity. Previous findings linking signals transmitted through T cell-expressed C5a receptor (C5aR) and C3a receptor (C3aR) to activation, differentiation, and expansion of conventional CD4(+)CD25(-) T cells (T conv cells), raised the possibility that C3aR/C5aR signaling on nT reg cells could… CONTINUE READING
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