Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

  title={Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells},
  author={Wing-Hong Kwan and William van der Touw and Estela Paz-Artal and Ming O Li and Peter S Heeger},
  booktitle={The Journal of experimental medicine},
Thymus-derived (natural) CD4(+) FoxP3(+) regulatory T cells (nT reg cells) are required for immune homeostasis and self-tolerance, but must be stringently controlled to permit expansion of protective immunity. Previous findings linking signals transmitted through T cell-expressed C5a receptor (C5aR) and C3a receptor (C3aR) to activation, differentiation, and expansion of conventional CD4(+)CD25(-) T cells (T conv cells), raised the possibility that C3aR/C5aR signaling on nT reg cells could… CONTINUE READING
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Publications referenced by this paper.
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CTLA-4 control over Foxp3+ regulatory T cell function.

Science • 2008
View 4 Excerpts
Highly Influenced

Locally produced C 5 a binds to T cell ­ expressed C 5 aR to enhance effector T ­ cell expansion by limiting antigen ­ induced apoptosis

M. G. Strainic, M. Yang, F. Lin, M. E. Medof, P. S. Heeger
Blood . • 2008
View 10 Excerpts
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Foxp3 programs

J. D. 1038nm.2155 Fontenot, M. A. Gavin, A. Y. Rudensky
View 3 Excerpts
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