Signaling states of rhodopsin. Retinal provides a scaffold for activating proton transfer switches.

@article{Meyer2000SignalingSO,
  title={Signaling states of rhodopsin. Retinal provides a scaffold for activating proton transfer switches.},
  author={Christian K. Meyer and Matthias B{\"o}hme and Axel Ockenfels and Wolfgang Gartner and Klaus Peter Hofmann and Oliver P Ernst},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 26},
  pages={
          19713-8
        }
}
The G-protein-coupled receptor rhodopsin is activated by photoconversion of its covalently bound ligand 11-cis-retinal to the agonist all-trans-retinal. After light-induced isomerization and early photointermediates, the receptor reaches a G-protein-dependent equilibrium between active and inactive conformations distinguished by the protonation of key opsin residues. In this report, we study the role of the 9-methyl group of retinal, one of the crucial steric determinants of light activation… CONTINUE READING
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