Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate.

@article{RodriguezViciana2004SignalingSB,
  title={Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate.},
  author={Pablo Rodriguez-Viciana and Celine Sabatier and Frank Mccormick},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 11},
  pages={4943-54}
}
Ras family GTPases (RFGs) regulate signaling pathways that control multiple biological processes. How signaling specificity among the closely related family members is achieved is poorly understood. We have taken a proteomics approach to signaling by RFGs, and we have analyzed interactions of a panel of RFGs with a comprehensive group of known and potential effectors. We have found remarkable differences in the ability of RFGs to regulate the various isoforms of known effector families. We have… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
120 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 120 extracted citations

Similar Papers

Loading similar papers…