Signaling pathways that control mRNA turnover.

Abstract

Cells regulate their genomes mainly at the level of transcription and at the level of mRNA decay. While regulation at the level of transcription is clearly important, the regulation of mRNA turnover by signaling networks is essential for a rapid response to external stimuli. Signaling pathways result in posttranslational modification of RNA binding proteins by phosphorylation, ubiquitination, methylation, acetylation etc. These modifications are important for rapid remodeling of dynamic ribonucleoprotein complexes and triggering mRNA decay. Understanding how these posttranslational modifications alter gene expression is therefore a fundamental question in biology. In this review we highlight recent findings on how signaling pathways and cell cycle checkpoints involving phosphorylation, ubiquitination, and arginine methylation affect mRNA turnover.

DOI: 10.1016/j.cellsig.2013.03.026
01002003002014201520162017
Citations per Year

137 Citations

Semantic Scholar estimates that this publication has 137 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Thapar2013SignalingPT, title={Signaling pathways that control mRNA turnover.}, author={Roopa Thapar and Andria P Denmon}, journal={Cellular signalling}, year={2013}, volume={25 8}, pages={1699-710} }