Signaling pathways that control cell proliferation.

  title={Signaling pathways that control cell proliferation.},
  author={Robert J. Duronio and Yue Xiong},
  journal={Cold Spring Harbor perspectives in biology},
  volume={5 3},
Cells decide to proliferate or remain quiescent using signaling pathways that link information about the cellular environment to the G1 phase of the cell cycle. Progression through G1 phase is controlled by pRB proteins, which function to repress the activity of E2F transcription factors in cells exiting mitosis and in quiescent cells. Phosphorylation of pRB proteins by the G1 cyclin-dependent kinases (CDKs) releases E2F factors, promoting the transition to S phase. CDK activity is primarily… CONTINUE READING


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