Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview.

@article{Tardito2006SignalingPR,
  title={Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview.},
  author={Daniela Tardito and Jorge P{\'e}rez and Ettore Tiraboschi and L Musazzi and Giorgio Racagni and Maurizio Popoli},
  journal={Pharmacological reviews},
  year={2006},
  volume={58 1},
  pages={115-34}
}
Regulation of gene expression represents a major component in antidepressant drug action. The effect of antidepressant treatments on the function of cAMP-responsive element binding protein (CREB), a transcription factor that regulates expression of several genes involved in neuroplasticity, cell survival, and cognition, has been extensively studied… CONTINUE READING