Signaling pathways regulating dose-dependent dual effects of TNF-α on primary cultured Schwann cells

@article{Tang2013SignalingPR,
  title={Signaling pathways regulating dose-dependent dual effects of TNF-α on primary cultured Schwann cells},
  author={Xin Tang and Yongjun Wang and Songlin Zhou and Tianmei Qian and Xiaosong Gu},
  journal={Molecular and Cellular Biochemistry},
  year={2013},
  volume={378},
  pages={237-246}
}
After peripheral nerve injury, Schwann cells are rapidly activated to participate in the regenerative process and modulate local immune reactions. Tumor necrosis factor-α (TNF-α), one of the major initiators of the inflammatory cascade, has been known to exert pleiotropic functions during peripheral nerve injury and regeneration. In this study, we aimed to investigate the in vitro effects of TNF-α on peripheral neural cells. First, gene-microarray analysis was applied to the RNA samples… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Similar Papers

Loading similar papers…