Signaling pathways of cardioprotective ischemic preconditioning.

  title={Signaling pathways of cardioprotective ischemic preconditioning.},
  author={Umar Sadat},
  journal={International journal of surgery},
  volume={7 6},
BACKGROUND Ischemia/reperfusion (I/R) injury is a major contributory factor to cardiac dysfunction and infarct size that determines patient prognosis after acute myocardial infarction. During the last 20 years, since the appearance of the first publication on ischemic preconditioning (IP), our knowledge of this phenomenon has increased exponentially. RESULTS AND CONCLUSION Basic scientific experiments and preliminary clinical trials in humans suggest that IP confers resistance to subsequent… CONTINUE READING