Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation.

@article{Wei2006SignalingPO,
  title={Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation.},
  author={Chun-yu Wei and Yin-Hsiang Chou and F C-S Ho and S. -C. Hsieh and Wan-Wan Lin},
  journal={Journal of cellular physiology},
  year={2006},
  volume={209 3},
  pages={735-43}
}
The biological actions of LIGHT, a member of the tumor necrosis factor superfamily, are mediated by the interaction with lymphotoxin-beta receptor (LTbetaR) and/or herpes virus entry mediator (HVEM). Previous study demonstrated high-level expressions of LIGHT and HVEM receptors in atherosclerotic plaques. To investigate the role of LIGHT in the functioning of macrophages and vascular smooth muscle cells (VSMC) in relation to atherogenesis, we determined the effects of LIGHT on macrophage… CONTINUE READING

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