Signaling pathways mediating anti-apoptotic action of neurotrophins.

  title={Signaling pathways mediating anti-apoptotic action of neurotrophins.},
  author={Michal Hetman and Zhengui Xia},
  journal={Acta neurobiologiae experimentalis},
  volume={60 4},
Neurotrophins promote survival and suppress apoptosis in many populations of neurons. Currently, phosphatidylinositol-3 kinase (PI-3K) is recognized as the main mediator of this protective effect. However, most of the data collected so far on the anti-apoptotic signaling of neurotrophins were obtained using trophic withdrawal paradigms. Recent data from our and other groups indicate that extracellular-signal-regulated kinase 1/2 (Erk 1/2) may play a critical role in suppressing neuronal… CONTINUE READING

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