Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2.

@article{SerranoSanchez2008SignalingPI,
  title={Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2.},
  author={Martin Serrano-Sanchez and Zahra Tanfin and Denis Leiber},
  journal={Endocrinology},
  year={2008},
  volume={149 9},
  pages={4669-79}
}
We investigated the regulation of the sphingosine kinase (SphK)/sphingosine-1-phosphate (S1P) axis and its role during pregnancy in the rat myometrium. SphK1 and SphK2 were coexpressed in myometrium during gestation. The levels and activity of SphK1/2 were modest at midgestation (d 12), increased at d 19 and progressively declined to low at postpartum. Similar patterns were observed for the phosphorylation of ERK and protein kinase C (PKC). Inhibition of PKC and ERK reduced SphK1/2 activity. In… CONTINUE READING

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SphK and COX2 in Pregnant Rat Myometrium at Shanghai Information Center for Life Sciences

  • A Kimura, M Ohmichi, +10 authors A Miyake
  • Endocrinology,
  • 2008
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