Signaling pathways involved in Ca2+- and Pb2+-induced vesicular catecholamine release from rat PC12 cells.

@article{Westerink2002SignalingPI,
  title={Signaling pathways involved in Ca2+- and Pb2+-induced vesicular catecholamine release from rat PC12 cells.},
  author={Remco H.S. Westerink and Andr{\'e} A. Klompmakers and Herman G. M. Westenberg and Henk P. M. Vijverberg},
  journal={Brain research},
  year={2002},
  volume={957 1},
  pages={25-36}
}
Since Pb(2+) substitutes for Ca(2+) in essential steps leading to exocytosis, we have investigated whether Ca(2+) and Pb(2+) induce exocytosis through similar pathways. Vesicular catecholamine release was measured from dexamethasone-differentiated PC12 cells using carbon fiber microelectrode amperometry. Effects of drugs known to modulate PKC (PMA… CONTINUE READING