Signaling pathways in intestinal development and cancer.

  title={Signaling pathways in intestinal development and cancer.},
  author={E. P{\'e}rez Sancho and Eduard Batlle and Hans Clevers},
  journal={Annual review of cell and developmental biology},
The study of the epithelium of the adult mammalian intestine touches upon many modern aspects of biology. The epithelium is in a constant dialogue with the underlying mesenchyme to control stem cell activity, proliferation in transit-amplifying compartments, lineage commitment, terminal differentiation and, ultimately, cell death. There are spatially distinct compartments dedicated to each of these events. The Wnt, TGF-beta, BMP, Notch, and Par polarity pathways are the major players in… CONTINUE READING