Signaling pathways in cell death and survival after photodynamic therapy.

@article{Moor2000SignalingPI,
  title={Signaling pathways in cell death and survival after photodynamic therapy.},
  author={A C Moor},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={2000},
  volume={57 1},
  pages={1-13}
}
  • A C Moor
  • Published 2000 in
    Journal of photochemistry and photobiology. B…
Photodynamic therapy (PDT) is a cytotoxic treatment, which can induce cells to initiate a rescue response, or to undergo cell death, either apoptosis or necrosis. The many signaling pathways involved in these processes are the topic of this review. The subcellular localization of the photosensitizer has been shown to be a key factor in the outcome of PDT. Mitochondrial localized photosensitizers are able to induce apoptosis very rapidly. Lysosomal localized photosensitizers can elicit either a… CONTINUE READING