Signaling pathways in T follicular helper cells.

  title={Signaling pathways in T follicular helper cells.},
  author={Julia Rolf and Kirsten A. Fairfax and Martin Turner},
  journal={Journal of immunology},
  volume={184 12},
Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through competition for Ag and for access to GC T cell-mediated prosurvival and differentiation signals. Because T cell help is one limiting factor for GC B cells, the molecular mechanisms… CONTINUE READING