Signaling pathways critical for allergic airway inflammation.

  title={Signaling pathways critical for allergic airway inflammation.},
  author={John D Colgan and Isaiah Luke Hankel},
  journal={Current opinion in allergy and clinical immunology},
  volume={10 1},
PURPOSE OF REVIEW Activated mast cells, basophils, and CD4 helper T cells have critical roles in allergic inflammation. Therefore, devising ways to specifically inhibit these cells will likely be useful for controlling allergic inflammation. We summarize recent findings regarding the role of mast cells and basophils in allergic responses and the regulation of signaling pathways downstream of the IgE receptor, the chief inducer of mast cell and basophil activation. We also highlight studies… CONTINUE READING
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