Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells.

@article{Vallier2009SignalingPC,
  title={Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells.},
  author={Ludovic Vallier and Thomas Touboul and Stephanie K. Brown and Candy H-H Cho and Bilada Bilican and Morgan R. Alexander and J Cedervall and Siddharthan Chandran and Lars Ahrlund-Richter and Anne C. Weber and Roger A. Pedersen},
  journal={Stem cells},
  year={2009},
  volume={27 11},
  pages={
          2655-66
        }
}
Human pluripotent stem cells from embryonic origins and those generated from reprogrammed somatic cells share many characteristics, including indefinite proliferation and a sustained capacity to differentiate into a wide variety of cell types. However, it remains to be demonstrated whether both cell types rely on similar mechanisms to maintain their pluripotent status and to control their differentiation. Any differences in such mechanisms would suggest that reprogramming of fibroblasts to… CONTINUE READING
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