Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.

@article{Rojo2012SignalingPA,
  title={Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.},
  author={Ana I. Rojo and Omar Noel Medina-Campos and Patricia Rada and Adverqueydi Z{\'u}{\~n}iga-Toal{\'a} and Areli L{\'o}pez-Gazc{\'o}n and Sandra Espada and Jos{\'e} Pedraza-Chaverri and Antonio Cuadrado},
  journal={Free radical biology & medicine},
  year={2012},
  volume={52 2},
  pages={473-87}
}
Defense against oxidative stress is executed by an antioxidant program that is tightly controlled by the transcription factor Nrf2. The stability of Nrf2 involves the interaction of two degradation domains, designated Neh2 and Neh6, with the E3 ubiquitin ligase adaptors, Keap1 and β-TrCP, respectively. The regulation of Nrf2 through the Neh6 degron remains largely unexplored but requires GSK-3 to form a phosphodegron. In this study, the cancer-chemopreventive agent nordihydroguaiaretic acid… CONTINUE READING

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