Signaling pathways activated by epidermal growth factor receptor or fibroblast growth factor receptor differentially regulate branching morphogenesis in fetal mouse submandibular glands.

@article{Koyama2008SignalingPA,
  title={Signaling pathways activated by epidermal growth factor receptor or fibroblast growth factor receptor differentially regulate branching morphogenesis in fetal mouse submandibular glands.},
  author={Noriko Koyama and Toru Hayashi and Kenji Ohno and Larry Siu and Edward W. Gresik and Masanori Kashimata},
  journal={Development, growth & differentiation},
  year={2008},
  volume={50 7},
  pages={565-76}
}
Although growth factor signaling is required for embryonic development of organs, individual signaling mechanisms regulating these organotypic processes are just beginning to be defined. We compared signaling activated in fetal mouse submandibular glands (SMGs) by three growth factors, epidermal growth factor (EGF), fibroblast growth factor (FGF) 7, or FGF10, and correlated it with specific events of branching morphogenesis. Immunoblotting showed that EGF strongly stimulated phosphorylation of… CONTINUE READING

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