Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin.

@article{Lefebvre1996SignalingPI,
  title={Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin.},
  author={Vincent Lefebvre and M. C. M{\'e}chin and M P Louckx and Mark H. Rider and Louis Hue},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 37},
  pages={
          22289-92
        }
}
Incubation of isolated rat cardiomyocytes with insulin increased 2-deoxyglucose uptake, glycogen synthesis, and fructose 2, 6-bisphosphate content. Half-maximal effects were obtained with 1-2 nM insulin. The insulin-induced increase in fructose 2,6-bisphosphate content was preceded by a 2-3-fold activation of 6-phosphofructo-2-kinase, which was independent of glucose transport. Insulin activated phosphatidylinositol 3-kinase and p70 ribosomal S6 kinase (p70 S6 kinase), but had no significant… CONTINUE READING

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