Signaling pathway for nitric oxide generation with simulated ischemia in flow-adapted endothelial cells.

@article{Wei2001SignalingPF,
  title={Signaling pathway for nitric oxide generation with simulated ischemia in flow-adapted endothelial cells.},
  author={Z Wei and Abu-Bakr Al-Mehdi and Aron B. Fisher},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 5},
  pages={
          H2226-32
        }
}
  • Z. Wei, A. Al-Mehdi, A. Fisher
  • Published 1 November 2001
  • Biology, Chemistry
  • American journal of physiology. Heart and circulatory physiology
Ischemia in the intact ventilated lung (oxygenated ischemia) leads to endothelial generation of reactive oxygen species (ROS) and nitric oxide (NO). This study investigated the signaling pathway for NO generation with oxygenated ischemia in bovine pulmonary artery endothelial cells (BPAEC) that were flow adapted in vitro. BPAECs were cultured in an artificial capillary system and subjected to abrupt cessation of flow (ischemia) under conditions where cellular oxygenation was maintained… 
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