Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for prostate cancer.

@article{Marcelli1999SignalingPA,
  title={Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for prostate cancer.},
  author={Marco Marcelli and Glenn R. Cunningham and Michael P. Walkup and Zhiwei He and Lydia T Sturgis and Carolyn Kagan and Roberta Mannucci and Ildo Nicoletti and Baiyu Teng and Larry A. Denner},
  journal={Cancer research},
  year={1999},
  volume={59 2},
  pages={
          382-90
        }
}
We studied the molecular mechanisms of apoptosis in the prostate cancer cell line LNCaP and whether overexpression of caspase activity could force this cell line to undergo apoptosis. The inhibitor of phosphomevalonate decarboxylase, sodium phenylacetate, and the protein kinase inhibitor staurosporine induced (a) release of cytochrome c from the mitochondria to the cytosol; (b) reduction in mitochondrial transmembrane potential; (c) proteolytic processing of caspase-3 and -7 but not -2; (d… CONTINUE READING

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